دانلود رایگان مقاله انگلیسی تشکیل سنگ کلیه در بیماران مبتلا به بیماری التهابی روده در جامعه به همراه ترجمه فارسی
|عنوان فارسی مقاله:||تشکیل سنگ کلیه در بیماران مبتلا به بیماری التهابی روده در جامعه|
|عنوان انگلیسی مقاله:||Nephrolithiasis in patients with inflammatory bowel disease in the community|
|رشته های مرتبط:||پزشکی، نفرولوژی و آسیب شناسی پزشکی|
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بخشی از ترجمه فارسی مقاله:
سنگ کلیه بیانگر یک مشکل جدی سلامتی در برخی از کشورها می باشد. برای مثال گزارش شده است که ۵%-۱۵% از کل جمعیت ایالات متحده در طول دوره زندگیشان با پیشرفت سنگ کلیه مواجه خواهند بود، درطول پنج سال که میزان عود (باز پیدایش) بیماری از ۳۰% به ۵۰% تغییر می یابد.
مواد و روش ها
بخشی از مقاله انگلیسی:
Nephrolithiasis represents a serious health problem in some countries. For instance, it has been reported that 5%–۱۵% of the general population in the United States will develop renal calculi in their lifetime, with the five-year recurrence rate ranging from 30% to 50%. Diet and gender are considered to be risk factors for the development of renal calculi, the incidence of which is higher in males. In the United States, nephrolithiasis accounts for 1% of all hospitalizations and is responsible for annual medical costs of two billion dollars.1–۴ Chronic diseases that are accompanied by intermittent diarrhea, such as ulcerative colitis and Crohn’s disease, are directly associated with the formation of renal calculi. Historical studies have demonstrated that the prevalence of symptomatic nephrolithiasis is higher in patients with inflammatory bowel disease (IBD, 7%–۱۵%) than in the general population (1%–۱۵%), typically in patients who have undergone extensive small bowel resection or in those with persistent severe small bowel inflammation.5,6 Extensive small bowel resections can lead to steatorrhea and increase the risk of hyperoxaluria by 28%, because these interventions can lead to loss of the bacterium Oxalobacter formigenes or chelation of free calcium in the colonic lumen by lipids.7 In addition, it has been reported that patients who have an ostomy are more likely to develop uric acid stones than calcium oxalate stones.6,8,9 In the last 10 years, new therapeutic approaches to patients with IBD have emerged and completely changed the natural history of these diseases; the impact of such approaches is reflected not only in lower rates of surgery but also in better prognoses, fewer hospitalizations, and better improved quality of life.9 Whether this has changed the prevalence of and risk factors for renal calculi in this patient population is unknown. The objective of the present study was to determine prospectively the prevalence of nephrolithiasis in a communitybased population of patients with IBD who had not undergone surgery. In addition, we sought to identify risk factors for formation of renal calculi in this population.
Materials and methods
We investigated a community-based population of patients with IBD treated between 2009 and 2012 at a clinic in the city of Campo Grande, located in the central-west region of Brazil. This was an analysis of prospectively collected data. Patients with ulcerative colitis were classified as having proctosigmoiditis, left-sided colitis, or pancolitis, whereas patients with Crohn’s disease were classified in accordance with the Vienna classification of Crohn’s disease. We determined disease activity using the Truelove–Witts index for patients with ulcerative colitis and the Crohn’s Disease Activity Index for patients with Crohn’s disease at the time of the index visit. At the first appointment with the gastroenterologist, an ultrasound of the kidneys and urinary tract was requested in order to screen for renal calculi, as is the clinical practice of the treating physician (DC). On the basis of the results, all patients with calculi or hydronephrosis were referred to a nephrologist for follow-up evaluation. We analyzed the electronic medical records of 168 patients monitored during the 12-month study period. The study was approved by the Universidade de São Paulo ethics committee (182330).
Continuous variables are presented as the mean and standard deviation, and categorical variables are presented as percentages. We used the Student’s t-test to analyze continuous variables, and used the chi-square test or Fisher’s exact test to analyze categorical variables. Odds ratios were calculated using 2 × ۲ tables of frequencies. All multivariate logistic regression analysis was undertaken for all variables significantly (P , 0.1) associated with the presence of renal calculi. Data were analyzed using the JMP program (SAS Institute, Cary, NC, USA)